Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Crotamine (TFA) | 98.1% | 4883.73 | 5 MG
Crotamine TFA is a Na+ channel modulator. It is a 42 amino acid toxin cross-linked by three disulfide bridges. It has analgesic activity and also interacts with lipid membranes, showing myonecrotic activity. Crotamine can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes
- Shows myonecrotic activity
- Isolated from *Crotalus durissus terrificus* venom
Medchemexpress LLC Ghrf, mouse (TFA) | 125199-49-7 | 98.9% | 5032.74 | 5 MG
GHRF, mouse (TFA) is a 44-amino acid peptide that stimulates the release and synthesis of growth hormone. This product is for research use only and not intended for patient use.
- 44-amino acid peptide
- Stimulates growth hormone release and synthesis
- High purity of 98.9%
- Molecular weight of 5032.74
- Increases growth hormone levels in LI-IGF-I-/- mice
Medchemexpress LLC LL-37 amide (TFA) | 99.34% | 4492.28 | 5 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens. It exerts bactericidal effects by activating immune cell chemotaxis and disrupting bacterial cell membrane integrity. This peptide also regulates inflammatory responses and promotes angiogenesis. Its amidation modification reduces sensitivity to serum inhibition and improves stability, making it suitable for research on infection-related diseases like periodontal disease, deep tissue injuries, and wound healing.
- Selective agonist of formyl peptide receptor-like FPRL1
- Inhibits periodontal pathogens
- Exerts bactericidal effects
- Regulates inflammatory responses
- Promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Useful in research for infection-related diseases and wound healing
- Effective against Gram-positive and Gram-negative bacteria
Medchemexpress LLC Dendrotoxin K TFA | 119128-61-9 | 6559.66 | 500 UG
Dendrotoxin K functions as a Kv1.1 channel blocker. It plays a role in determining glutamate release within CA3 neurons by controlling the presynaptic spike waveform in a time-dependent manner.
- Acts as a Kv1.1 channel blocker.
- Influences glutamate release in CA3 neurons.
- Regulates the presynaptic spike waveform in a time-dependent manner.
- Intended for research use only.
Medchemexpress LLC PHF6 TFA | 99.5% | 748.91 | 5 MG
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein.
- Aggregated tau-PHF6 (VQIVYK) TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells.
Medchemexpress LLC Api137 | 1428789-03-0 | 2291.71 | 5 MG
Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. It inhibits protein synthesis by trapping release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain.
- Acts as an antimicrobial peptide
- Interferes with bacterial growth by inhibiting translation
- Inhibits protein synthesis by trapping release factors on the 70S ribosome
- Follows hydrolysis of the nascent polypeptide chain
