Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC BRP TFA (BRINP2-related peptide TFA) | 1540.88 (free base) | 1 MG
BRP (BRINP2-related peptide) TFA possesses anti-obesity activity via FOS activation. This peptide activates FOS in the central nervous system and acts independently of leptin, GLP-1 receptor, and melanocortin 4 receptor. It is intended for research use only.
- Anti-obesity activity
- FOS activation
- Activates FOS in the central nervous system
- Acts independently of leptin
- Acts independently of GLP-1 receptor
- Acts independently of melanocortin 4 receptor
Medchemexpress LLC Bibo3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g·mol⁻¹ | C31H36F3N7O5 | 10 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used in pharmacological and receptor biology research. Supplied as a trifluoroacetate salt in solid form, it is characterized by a defined molecular formula and molecular weight and is intended for in vitro and in vivo experimental applications.
- Potent NPY Y1 receptor antagonist with subnanomolar affinity.
- High reported purity suitable for research-grade assays.
- Stable solid trifluoroacetate salt for convenient handling and storage.
- Available in small milligram quantities and pre-made DMSO solutions for assay readiness.
- Characterized molecular weight and formula to support analytical and dosing calculations.
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC DEC-RVRK-CMK TFA | 96.1% | 744.41 | 1 MG
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position. It is for research use only.
- Peptide-based CMK inhibitor
- Targets and inactivates secreted soluble kexin (Kex2)
- Ki of 8.45 μM against ssKex2
- Inhibits yeast enzyme Kex2 (kexin, EC 3.4.21.61)
- Calcium-dependent transmembrane protease
- Useful for studying binding mechanisms and substrate selectivity
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo500G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo500G
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 5 MG
PBX-7011 TFA is a derivative of camptothecin. It inhibits expressions of the cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells, degrades DDX5 proteins, and exhibits anticancer activity.
- Inhibits expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 5 MG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. GIP, along with GLP, stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest a role for GIP in lipid homeostasis and a potential function in the pathogenesis of obesity.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Released by K cells in duodenum and jejunum
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Plays a role in lipid homeostasis
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.09% | 2675.03 | 25 MG
KRpep-2d TFA is a potent K-Ras inhibitor that inhibits the proliferation of K-Ras-driven cancer cells. It possesses a cyclic structure, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for its K-Ras inhibitory activity. This peptide can be used for cancer research.
- Potent K-Ras inhibitor
- Inhibits proliferation of K-Ras-driven cancer cells
- Cyclic structure important for inhibitory activity
- Demonstrates inhibitory activity in A427 cells
- Targets Ras
- Involved in GPCR/G Protein and MAPK/ERK Pathway
Medchemexpress LLC JTP10-△-TATi TFA | 99.7% | 2833.28 | 5 MG
JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor that exhibits 10-fold selectivity for JNK2 over JNK1 and JNK3. It has an IC50 of 92 nM for JNK2 and can inhibit the migration of PyVMTjnk2+/+ cells.
- Selective JNK2 peptide inhibitor
- IC50 of 92 nM for JNK2
- 10-fold selectivity over JNK1 and JNK3
- Inhibits migration of PyVMTjnk2+/+ cells
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 74838-83-8 | 98.6% | 367.32 | 5 MG
Cyclo(Arg-Pro) TFA is a chitinase inhibitor that disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. It prevents cell separation of *Saccharomyces cerevisiae*, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Additionally, it blocks the morphological transition of *Candida albicans* from yeast form to hyphal form, without inhibiting cell growth.
- Disrupts cell separation and morphological transition of yeast
- Prevents cell separation of *Saccharomyces cerevisiae*
- Leads to formation of grape-like cell clusters
- Blocks morphological transition of *Candida albicans* from yeast form to hyphal form
Medchemexpress LLC CMD178 TFA | 99.7% | 964.05 | 5 MG
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Ra signaling. It also acts as an inhibitor of STAT5 and inhibits Treg cells development.
- Reduces expression of Foxp3 and STAT5 induced by IL-2/s IL-2Ra signaling
- Inhibits STAT5
- Inhibits Treg cells development
Medchemexpress LLC Ms15 TFA | C66H80F3N11O7S | 5 MG
MS15 TFA is a potent and selective AKT PROTAC degrader for research use only. It effectively inhibits AKT1, AKT2, and AKT3 activities, demonstrating bioavailability in mice through intraperitoneal administration.
- Potent and selective AKT PROTAC degrader
- Inhibits AKT1, -2, and -3 activities
- IC50 values: 798 nM (AKT-1), 90 nM (AKT-2), 544 nM (AKT-3)
- Bioavailable in mice via intraperitoneal administration
- Purity of 99.82%
Medchemexpress LLC Wrwyar-NH2 TFA | 70.8% | 936.07 | 5 MG
Wrwyar-NH2 TFA is a control peptide primarily targeting DNA/RNA synthesis. It plays a role in the Cell Cycle/DNA Damage pathway. This product is intended for research use only and has not been fully validated for medical applications.
- Control peptide
- Targets DNA/RNA synthesis
- Involved in cell cycle/DNA damage pathway
- For research use only
Medchemexpress LLC FRETS-VWF73 (TFA) | 96.8% | 9340.61 | 500 UG
FRETS-VWF73 (TFA) is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay. This peptide is utilized as a predictive tool for thrombotic thrombocytopenic purpura, offering a valuable resource for research and diagnostic applications.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Used as a predictive tool for thrombotic thrombocytopenic purpura
- Excitation at 340 nm; emission at 450 nm